Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521675..3522295 Replicon chromosome
Accession NZ_CP120333
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_8_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1827_RS17500 Protein ID WP_001280991.1
Coordinates 3522077..3522295 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1827_RS17495 Protein ID WP_000344807.1
Coordinates 3521675..3522049 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1827_RS17485 (3516814) 3516814..3518007 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1827_RS17490 (3518030) 3518030..3521179 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1827_RS17495 (3521675) 3521675..3522049 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1827_RS17500 (3522077) 3522077..3522295 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1827_RS17505 (3522474) 3522474..3523025 + 552 WP_001278792.1 maltose O-acetyltransferase -
P1827_RS17510 (3523142) 3523142..3523612 + 471 WP_000136181.1 YlaC family protein -
P1827_RS17515 (3523668) 3523668..3523808 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1827_RS17520 (3523814) 3523814..3524074 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1827_RS17525 (3524299) 3524299..3525849 + 1551 WP_000213140.1 EAL domain-containing protein -
P1827_RS17535 (3526080) 3526080..3526469 + 390 WP_000961285.1 MGMT family protein -
P1827_RS17540 (3526502) 3526502..3527071 - 570 WP_020437370.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274738 WP_001280991.1 NZ_CP120333:3522077-3522295 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274738 WP_000344807.1 NZ_CP120333:3521675-3522049 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References