Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1017318..1018132 Replicon chromosome
Accession NZ_CP120333
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_8_2021

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1827_RS04905 Protein ID WP_000971655.1
Coordinates 1017318..1017845 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1827_RS04910 Protein ID WP_000855694.1
Coordinates 1017842..1018132 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1827_RS04875 (1013618) 1013618..1014015 + 398 Protein_955 cytoplasmic protein -
P1827_RS04880 (1014206) 1014206..1014445 + 240 Protein_956 hypothetical protein -
P1827_RS04885 (1014602) 1014602..1015270 + 669 WP_000445914.1 hypothetical protein -
P1827_RS04890 (1015297) 1015297..1015791 + 495 WP_000424942.1 hypothetical protein -
P1827_RS04895 (1016036) 1016036..1016692 - 657 WP_020437799.1 protein-serine/threonine phosphatase -
P1827_RS04900 (1017030) 1017030..1017245 + 216 Protein_960 IS5/IS1182 family transposase -
P1827_RS04905 (1017318) 1017318..1017845 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1827_RS04910 (1017842) 1017842..1018132 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1827_RS04915 (1018402) 1018402..1018602 - 201 Protein_963 transposase -
P1827_RS04920 (1018843) 1018843..1019169 + 327 WP_000393302.1 hypothetical protein -
P1827_RS04925 (1019442) 1019442..1019789 - 348 WP_001669174.1 DUF1493 family protein -
P1827_RS04930 (1019774) 1019774..1020223 - 450 WP_021294302.1 hypothetical protein -
P1827_RS04935 (1020655) 1020655..1021098 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1827_RS04940 (1021554) 1021554..1022204 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1017105..1017245 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T274733 WP_000971655.1 NZ_CP120333:c1017845-1017318 [Salmonella enterica subsp. enterica serovar Muenchen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274733 WP_000855694.1 NZ_CP120333:c1018132-1017842 [Salmonella enterica subsp. enterica serovar Muenchen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References