Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 58602..58963 Replicon chromosome
Accession NC_017646
Organism Escherichia coli O7:K1 str. CE10

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CE10_RS30615 Protein ID WP_001160960.1
Coordinates 58838..58963 (+) Length 42 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag CE10_RS00285 Protein ID WP_000125568.1
Coordinates 58602..58835 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE10_RS00260 53676..53963 + 288 WP_000203741.1 ferredoxin-like protein FixX -
CE10_RS00265 54021..55352 + 1332 Protein_47 MFS transporter -
CE10_RS00270 55460..55990 + 531 WP_000600730.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
CE10_RS00275 55983..57845 + 1863 WP_000377135.1 glutathione-regulated potassium-efflux system protein KefC -
CE10_RS00280 58037..58516 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
CE10_RS00285 58602..58835 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CE10_RS30615 58838..58963 + 126 WP_001160960.1 CcdB family protein Toxin
CE10_RS30620 59012..59152 + 141 WP_165832382.1 CcdB family protein -
CE10_RS00295 59149..59997 - 849 WP_000257195.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
CE10_RS00300 60004..60381 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
CE10_RS00305 60384..61205 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CE10_RS00310 61202..62191 - 990 WP_000241224.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
CE10_RS00315 62191..63477 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-40)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4706.49 Da        Isoelectric Point: 8.7956

>T27473 WP_001160960.1 NC_017646:58838-58963 [Escherichia coli O7:K1 str. CE10]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIE

Download         Length: 126 bp

>T27473 NC_017646:58838-58963 [Escherichia coli O7:K1 str. CE10]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT27473 WP_000125568.1 NC_017646:58602-58835 [Escherichia coli O7:K1 str. CE10]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT27473 NC_017646:58602-58835 [Escherichia coli O7:K1 str. CE10]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References