274711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4488131..4488747 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag P1707_RS21560 Protein ID WP_000238494.1
Coordinates 4488131..4488505 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag P1707_RS21565 Protein ID WP_001523745.1
Coordinates 4488505..4488747 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS21545 (4485633) 4485633..4486535 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1707_RS21550 (4486532) 4486532..4487167 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1707_RS21555 (4487164) 4487164..4488093 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1707_RS21560 (4488131) 4488131..4488505 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
P1707_RS21565 (4488505) 4488505..4488747 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
P1707_RS21570 (4488952) 4488952..4489881 + 930 WP_053445360.1 alpha/beta hydrolase -
P1707_RS21575 (4489967) 4489967..4490278 + 312 WP_060598552.1 type II toxin-antitoxin system HigB family toxin -
P1707_RS21580 (4490275) 4490275..4490721 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
P1707_RS21585 (4490736) 4490736..4491677 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1707_RS21590 (4491722) 4491722..4492159 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
P1707_RS21595 (4492156) 4492156..4493028 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1707_RS21600 (4493022) 4493022..4493621 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T274711 WP_000238494.1 NZ_CP120329:c4488505-4488131 [Salmonella enterica subsp. enterica serovar Muenchen]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT274711 WP_001523745.1 NZ_CP120329:c4488747-4488505 [Salmonella enterica subsp. enterica serovar Muenchen]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References