Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3388012..3388632 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1707_RS16500 Protein ID WP_001280991.1
Coordinates 3388414..3388632 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1707_RS16495 Protein ID WP_000344807.1
Coordinates 3388012..3388386 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS16485 (3383151) 3383151..3384344 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1707_RS16490 (3384367) 3384367..3387516 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1707_RS16495 (3388012) 3388012..3388386 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1707_RS16500 (3388414) 3388414..3388632 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1707_RS16505 (3388811) 3388811..3389362 + 552 WP_053444946.1 maltose O-acetyltransferase -
P1707_RS16510 (3389479) 3389479..3389949 + 471 WP_000136181.1 YlaC family protein -
P1707_RS16515 (3390005) 3390005..3390145 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1707_RS16520 (3390151) 3390151..3390363 - 213 WP_283903176.1 50S ribosomal protein L31 -
P1707_RS16525 (3390537) 3390537..3392072 + 1536 WP_023181050.1 IS21 family transposase -
P1707_RS16530 (3392089) 3392089..3392844 + 756 WP_001282653.1 IS21-like element ISSso4 family helper ATPase IstB -
P1707_RS16535 (3392938) 3392938..3393057 - 120 Protein_3234 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274709 WP_001280991.1 NZ_CP120329:3388414-3388632 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274709 WP_000344807.1 NZ_CP120329:3388012-3388386 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References