Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2353150..2353672 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name stbE Uniprot ID A0A3Y0CYW1
Locus tag P1707_RS11510 Protein ID WP_053445270.1
Coordinates 2353150..2353434 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag P1707_RS11515 Protein ID WP_000885424.1
Coordinates 2353424..2353672 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS11485 (2348306) 2348306..2349547 - 1242 WP_001095738.1 MFS transporter -
P1707_RS11490 (2349537) 2349537..2351045 - 1509 WP_053445272.1 FAD-dependent oxidoreductase -
P1707_RS11495 (2351090) 2351090..2351578 + 489 WP_023258342.1 MarR family winged helix-turn-helix transcriptional regulator -
P1707_RS11500 (2351771) 2351771..2352850 + 1080 WP_053445271.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P1707_RS11505 (2352950) 2352950..2353102 - 153 Protein_2251 Rid family hydrolase -
P1707_RS11510 (2353150) 2353150..2353434 - 285 WP_053445270.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1707_RS11515 (2353424) 2353424..2353672 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1707_RS11520 (2354198) 2354198..2354530 + 333 WP_053445269.1 DUF1493 family protein -
P1707_RS11525 (2354819) 2354819..2355100 - 282 WP_001580000.1 hypothetical protein -
P1707_RS11530 (2355388) 2355388..2356854 - 1467 WP_077248432.1 hypothetical protein -
P1707_RS11535 (2357112) 2357112..2358119 + 1008 WP_053445268.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11074.91 Da        Isoelectric Point: 10.8165

>T274708 WP_053445270.1 NZ_CP120329:c2353434-2353150 [Salmonella enterica subsp. enterica serovar Muenchen]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRKRLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT274708 WP_000885424.1 NZ_CP120329:c2353672-2353424 [Salmonella enterica subsp. enterica serovar Muenchen]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0CYW1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References