Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 989967..990781 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3Y0CWF0
Locus tag P1707_RS04740 Protein ID WP_053444849.1
Coordinates 989967..990494 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1707_RS04745 Protein ID WP_000855694.1
Coordinates 990491..990781 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS04720 985270..987837 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P1707_RS04725 987996..988516 + 521 Protein_925 cytoplasmic protein -
P1707_RS04730 988686..989342 - 657 WP_053444848.1 protein-serine/threonine phosphatase -
P1707_RS04735 989692..989894 + 203 Protein_927 IS5/IS1182 family transposase -
P1707_RS04740 989967..990494 - 528 WP_053444849.1 GNAT family N-acetyltransferase Toxin
P1707_RS04745 990491..990781 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1707_RS04750 991051..991251 - 201 Protein_930 transposase -
P1707_RS04755 991492..991818 + 327 WP_000393302.1 hypothetical protein -
P1707_RS04760 992091..992438 - 348 WP_001669174.1 DUF1493 family protein -
P1707_RS04765 992423..992872 - 450 WP_000381612.1 membrane protein -
P1707_RS04770 993305..993748 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1707_RS04775 994206..994856 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 989718..989894 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19027.81 Da        Isoelectric Point: 9.6420

>T274703 WP_053444849.1 NZ_CP120329:c990494-989967 [Salmonella enterica subsp. enterica serovar Muenchen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVSLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274703 WP_000855694.1 NZ_CP120329:c990781-990491 [Salmonella enterica subsp. enterica serovar Muenchen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0CWF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References