Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835846..836471 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1707_RS04065 Protein ID WP_000911337.1
Coordinates 836073..836471 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P1707_RS04060 Protein ID WP_000557549.1
Coordinates 835846..836073 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS04030 (830909) 830909..832007 + 1099 WP_010989230.1 peptide chain release factor 2 -
P1707_RS04035 (832017) 832017..833534 + 1518 WP_000003339.1 lysine--tRNA ligase -
P1707_RS04040 (833610) 833610..834155 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P1707_RS04045 (834420) 834420..835178 + 759 WP_000244328.1 amidase activator ActS -
P1707_RS04055 (835424) 835424..835637 - 214 Protein_793 hypothetical protein -
P1707_RS04060 (835846) 835846..836073 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1707_RS04065 (836073) 836073..836471 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
P1707_RS04070 (837276) 837276..837812 + 537 WP_053444818.1 STM3031 family outer membrane protein -
P1707_RS04075 (837851) 837851..838483 + 633 WP_023232674.1 YfdX family protein -
P1707_RS04080 (838803) 838803..839558 - 756 WP_001282653.1 IS21-like element ISSso4 family helper ATPase IstB -
P1707_RS04085 (839575) 839575..841110 - 1536 WP_023181050.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T274702 WP_000911337.1 NZ_CP120329:836073-836471 [Salmonella enterica subsp. enterica serovar Muenchen]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274702 WP_000557549.1 NZ_CP120329:835846-836073 [Salmonella enterica subsp. enterica serovar Muenchen]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References