Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 205843..206603 Replicon chromosome
Accession NZ_CP120329
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P1707_RS00975 Protein ID WP_000533909.1
Coordinates 206118..206603 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P1707_RS00970 Protein ID WP_000965886.1
Coordinates 205843..206130 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1707_RS00950 (201248) 201248..202159 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
P1707_RS00955 (202169) 202169..204238 + 2070 WP_020437730.1 glycine--tRNA ligase subunit beta -
P1707_RS00960 (204628) 204628..205056 + 429 Protein_190 IS3 family transposase -
P1707_RS00965 (205198) 205198..205665 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
P1707_RS00970 (205843) 205843..206130 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P1707_RS00975 (206118) 206118..206603 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P1707_RS00980 (206974) 206974..207513 - 540 WP_000047139.1 copper-binding periplasmic metallochaperone CueP -
P1707_RS00985 (207687) 207687..207899 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P1707_RS00990 (208187) 208187..208477 - 291 WP_000455790.1 HTH-type transcriptional regulator -
P1707_RS00995 (208916) 208916..209626 + 711 WP_000190524.1 DUF3053 domain-containing protein -
P1707_RS01000 (209676) 209676..210650 - 975 WP_053445130.1 glyoxylate/hydroxypyruvate reductase GhrB -
P1707_RS01005 (210869) 210869..211531 - 663 WP_053445131.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T274700 WP_000533909.1 NZ_CP120329:206118-206603 [Salmonella enterica subsp. enterica serovar Muenchen]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT274700 WP_000965886.1 NZ_CP120329:205843-206130 [Salmonella enterica subsp. enterica serovar Muenchen]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References