Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4467217..4467877 Replicon chromosome
Accession NZ_CP120327
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1825_RS21820 Protein ID WP_000244756.1
Coordinates 4467217..4467630 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1825_RS21825 Protein ID WP_000351186.1
Coordinates 4467611..4467877 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1825_RS21800 (4463158) 4463158..4464891 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
P1825_RS21805 (4464897) 4464897..4465610 - 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1825_RS21810 (4465634) 4465634..4466530 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1825_RS21815 (4466643) 4466643..4467164 + 522 WP_001055885.1 flavodoxin FldB -
P1825_RS21820 (4467217) 4467217..4467630 - 414 WP_000244756.1 protein YgfX Toxin
P1825_RS21825 (4467611) 4467611..4467877 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1825_RS21830 (4468127) 4468127..4469107 + 981 WP_000874175.1 tRNA-modifying protein YgfZ -
P1825_RS21835 (4469223) 4469223..4469882 - 660 WP_000250289.1 hemolysin III family protein -
P1825_RS21840 (4470046) 4470046..4470357 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1825_RS21845 (4470516) 4470516..4471949 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T274695 WP_000244756.1 NZ_CP120327:c4467630-4467217 [Salmonella enterica subsp. enterica serovar Muenchen]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT274695 WP_000351186.1 NZ_CP120327:c4467877-4467611 [Salmonella enterica subsp. enterica serovar Muenchen]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References