Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4304462..4305276 Replicon chromosome
Accession NZ_CP120327
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1825_RS21075 Protein ID WP_000971655.1
Coordinates 4304749..4305276 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1825_RS21070 Protein ID WP_000855694.1
Coordinates 4304462..4304752 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1825_RS21040 (4300390) 4300390..4301040 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
P1825_RS21045 (4301496) 4301496..4301939 + 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1825_RS21050 (4302371) 4302371..4302820 + 450 WP_021294302.1 hypothetical protein -
P1825_RS21055 (4302805) 4302805..4303152 + 348 WP_001669174.1 DUF1493 family protein -
P1825_RS21060 (4303425) 4303425..4303751 - 327 WP_000393302.1 hypothetical protein -
P1825_RS21065 (4303992) 4303992..4304192 + 201 Protein_4104 transposase -
P1825_RS21070 (4304462) 4304462..4304752 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1825_RS21075 (4304749) 4304749..4305276 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1825_RS21080 (4305349) 4305349..4305564 - 216 Protein_4107 IS5/IS1182 family transposase -
P1825_RS21085 (4305902) 4305902..4306558 + 657 WP_020437799.1 protein-serine/threonine phosphatase -
P1825_RS21090 (4306803) 4306803..4307297 - 495 WP_000424942.1 hypothetical protein -
P1825_RS21095 (4307324) 4307324..4307992 - 669 WP_000445914.1 hypothetical protein -
P1825_RS21100 (4308149) 4308149..4308388 - 240 Protein_4111 hypothetical protein -
P1825_RS21105 (4308579) 4308579..4308976 - 398 Protein_4112 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4305349..4305489 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T274694 WP_000971655.1 NZ_CP120327:4304749-4305276 [Salmonella enterica subsp. enterica serovar Muenchen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274694 WP_000855694.1 NZ_CP120327:4304462-4304752 [Salmonella enterica subsp. enterica serovar Muenchen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References