Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1800288..1800908 Replicon chromosome
Accession NZ_CP120327
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1825_RS08470 Protein ID WP_001280991.1
Coordinates 1800288..1800506 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1825_RS08475 Protein ID WP_000344807.1
Coordinates 1800534..1800908 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1825_RS08430 (1795512) 1795512..1796081 + 570 WP_020437370.1 YbaY family lipoprotein -
P1825_RS08435 (1796114) 1796114..1796503 - 390 WP_000961285.1 MGMT family protein -
P1825_RS08445 (1796734) 1796734..1798284 - 1551 WP_000213140.1 EAL domain-containing protein -
P1825_RS08450 (1798509) 1798509..1798769 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1825_RS08455 (1798775) 1798775..1798915 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1825_RS08460 (1798971) 1798971..1799441 - 471 WP_000136181.1 YlaC family protein -
P1825_RS08465 (1799558) 1799558..1800109 - 552 WP_001278792.1 maltose O-acetyltransferase -
P1825_RS08470 (1800288) 1800288..1800506 - 219 WP_001280991.1 HHA domain-containing protein Toxin
P1825_RS08475 (1800534) 1800534..1800908 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1825_RS08480 (1801404) 1801404..1804553 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1825_RS08485 (1804576) 1804576..1805769 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274689 WP_001280991.1 NZ_CP120327:c1800506-1800288 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274689 WP_000344807.1 NZ_CP120327:c1800908-1800534 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References