Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1105524..1106040 Replicon chromosome
Accession NZ_CP120327
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P1825_RS05215 Protein ID WP_000220578.1
Coordinates 1105756..1106040 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P1825_RS05210 Protein ID WP_000212724.1
Coordinates 1105524..1105766 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1825_RS05190 (1100544) 1100544..1101677 + 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -
P1825_RS05195 (1101661) 1101661..1102779 + 1119 WP_023197793.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1825_RS05200 (1102776) 1102776..1103516 + 741 WP_000779259.1 KDGP aldolase family protein -
P1825_RS05205 (1103533) 1103533..1105446 + 1914 WP_001212145.1 BglG family transcription antiterminator -
P1825_RS05210 (1105524) 1105524..1105766 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P1825_RS05215 (1105756) 1105756..1106040 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1825_RS05220 (1106044) 1106044..1106508 - 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1825_RS05225 (1106725) 1106725..1108863 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1825_RS05230 (1109272) 1109272..1110924 - 1653 WP_021294549.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T274685 WP_000220578.1 NZ_CP120327:1105756-1106040 [Salmonella enterica subsp. enterica serovar Muenchen]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT274685 WP_000212724.1 NZ_CP120327:1105524-1105766 [Salmonella enterica subsp. enterica serovar Muenchen]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References