Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4216537..4217053 Replicon chromosome
Accession NZ_CP120325
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_11_2021

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P1704_RS20755 Protein ID WP_000220578.1
Coordinates 4216537..4216821 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P1704_RS20760 Protein ID WP_000212724.1
Coordinates 4216811..4217053 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1704_RS20740 (4211653) 4211653..4213305 + 1653 WP_021294549.1 alpha,alpha-phosphotrehalase -
P1704_RS20745 (4213714) 4213714..4215852 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1704_RS20750 (4216069) 4216069..4216533 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1704_RS20755 (4216537) 4216537..4216821 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1704_RS20760 (4216811) 4216811..4217053 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P1704_RS20765 (4217131) 4217131..4219044 - 1914 WP_001212145.1 BglG family transcription antiterminator -
P1704_RS20770 (4219061) 4219061..4219801 - 741 WP_000779259.1 KDGP aldolase family protein -
P1704_RS20775 (4219798) 4219798..4220916 - 1119 WP_023197793.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1704_RS20780 (4220900) 4220900..4222033 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T274675 WP_000220578.1 NZ_CP120325:c4216821-4216537 [Salmonella enterica subsp. enterica serovar Muenchen]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT274675 WP_000212724.1 NZ_CP120325:c4217053-4216811 [Salmonella enterica subsp. enterica serovar Muenchen]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References