Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4551967..4552727 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag P1705_RS22325 Protein ID WP_000533912.1
Coordinates 4551967..4552452 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P1705_RS22330 Protein ID WP_000965886.1
Coordinates 4552440..4552727 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS22295 (4547039) 4547039..4547701 + 663 WP_000747548.1 OmpA family lipoprotein -
P1705_RS22300 (4547920) 4547920..4548894 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
P1705_RS22305 (4548944) 4548944..4549654 - 711 WP_000190524.1 DUF3053 domain-containing protein -
P1705_RS22310 (4550093) 4550093..4550383 + 291 WP_000455790.1 HTH-type transcriptional regulator -
P1705_RS22315 (4550671) 4550671..4550883 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P1705_RS22320 (4551057) 4551057..4551596 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
P1705_RS22325 (4551967) 4551967..4552452 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
P1705_RS22330 (4552440) 4552440..4552727 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P1705_RS22335 (4552905) 4552905..4553372 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
P1705_RS22340 (4553544) 4553544..4553942 - 399 Protein_4327 IS3 family transposase -
P1705_RS22345 (4554332) 4554332..4556401 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
P1705_RS22350 (4556411) 4556411..4557322 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T274661 WP_000533912.1 NZ_CP120322:c4552452-4551967 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT274661 WP_000965886.1 NZ_CP120322:c4552727-4552440 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References