Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3927211..3927871 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1705_RS19285 Protein ID WP_000244756.1
Coordinates 3927211..3927624 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1705_RS19290 Protein ID WP_000351186.1
Coordinates 3927605..3927871 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS19265 (3923152) 3923152..3924885 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
P1705_RS19270 (3924891) 3924891..3925604 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1705_RS19275 (3925628) 3925628..3926524 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1705_RS19280 (3926637) 3926637..3927158 + 522 WP_001055885.1 flavodoxin FldB -
P1705_RS19285 (3927211) 3927211..3927624 - 414 WP_000244756.1 protein YgfX Toxin
P1705_RS19290 (3927605) 3927605..3927871 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1705_RS19295 (3928121) 3928121..3929101 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
P1705_RS19300 (3929217) 3929217..3929876 - 660 WP_000250289.1 hemolysin III family protein -
P1705_RS19305 (3930040) 3930040..3930351 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1705_RS19310 (3930509) 3930509..3931942 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T274658 WP_000244756.1 NZ_CP120322:c3927624-3927211 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT274658 WP_000351186.1 NZ_CP120322:c3927871-3927605 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References