Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1306452..1307072 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1705_RS06190 Protein ID WP_001280991.1
Coordinates 1306452..1306670 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1705_RS06195 Protein ID WP_000344807.1
Coordinates 1306698..1307072 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS06150 (1301675) 1301675..1302244 + 570 WP_000779802.1 YbaY family lipoprotein -
P1705_RS06155 (1302277) 1302277..1302666 - 390 WP_000961287.1 MGMT family protein -
P1705_RS06165 (1302897) 1302897..1304447 - 1551 WP_000213140.1 EAL domain-containing protein -
P1705_RS06170 (1304672) 1304672..1304932 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1705_RS06175 (1304938) 1304938..1305078 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1705_RS06180 (1305134) 1305134..1305604 - 471 WP_000136183.1 YlaC family protein -
P1705_RS06185 (1305722) 1305722..1306273 - 552 WP_001278793.1 maltose O-acetyltransferase -
P1705_RS06190 (1306452) 1306452..1306670 - 219 WP_001280991.1 HHA domain-containing protein Toxin
P1705_RS06195 (1306698) 1306698..1307072 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1705_RS06200 (1307568) 1307568..1310717 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1705_RS06205 (1310740) 1310740..1311933 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274650 WP_001280991.1 NZ_CP120322:c1306670-1306452 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274650 WP_000344807.1 NZ_CP120322:c1307072-1306698 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References