Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 730963..731539 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag P1705_RS03545 Protein ID WP_001131963.1
Coordinates 730963..731250 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag P1705_RS03550 Protein ID WP_000063142.1
Coordinates 731237..731539 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS03520 (726071) 726071..726205 + 135 WP_001055725.1 hypothetical protein -
P1705_RS03525 (726237) 726237..727490 - 1254 WP_001206755.1 N-6 DNA methylase -
P1705_RS03530 (727495) 727495..727839 - 345 WP_283903125.1 restriction endonuclease subunit S -
P1705_RS03535 (727826) 727826..728074 - 249 WP_283903126.1 hypothetical protein -
P1705_RS03540 (728684) 728684..730525 - 1842 WP_283903127.1 3'-5' exonuclease -
P1705_RS03545 (730963) 730963..731250 + 288 WP_001131963.1 BrnT family toxin Toxin
P1705_RS03550 (731237) 731237..731539 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
P1705_RS03555 (731614) 731614..732570 - 957 WP_000187843.1 GTPase -
P1705_RS03560 (732581) 732581..732784 - 204 WP_000460616.1 YbdD/YjiX family protein -
P1705_RS03565 (732879) 732879..735029 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T274647 WP_001131963.1 NZ_CP120322:730963-731250 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT274647 WP_000063142.1 NZ_CP120322:731237-731539 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References