Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 639614..640130 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag P1705_RS03100 Protein ID WP_000220582.1
Coordinates 639846..640130 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P1705_RS03095 Protein ID WP_000212724.1
Coordinates 639614..639856 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS03075 (634635) 634635..635768 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
P1705_RS03080 (635752) 635752..636870 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1705_RS03085 (636867) 636867..637606 + 740 Protein_566 KDGP aldolase family protein -
P1705_RS03090 (637623) 637623..639536 + 1914 WP_001212142.1 BglG family transcription antiterminator -
P1705_RS03095 (639614) 639614..639856 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P1705_RS03100 (639846) 639846..640130 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1705_RS03105 (640134) 640134..640598 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1705_RS03110 (640720) 640720..642858 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1705_RS03115 (643267) 643267..644919 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T274645 WP_000220582.1 NZ_CP120322:639846-640130 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT274645 WP_000212724.1 NZ_CP120322:639614-639856 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References