Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 532453..533234 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P1705_RS02525 Protein ID WP_000626100.1
Coordinates 532743..533234 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1705_RS02520 Protein ID WP_001110452.1
Coordinates 532453..532746 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS02485 (528500) 528500..529405 + 906 WP_001268200.1 YjiK family protein -
P1705_RS02490 (529699) 529699..529830 - 132 Protein_451 hypothetical protein -
P1705_RS02495 (529942) 529942..530190 - 249 Protein_452 Ig-like domain-containing protein -
P1705_RS02500 (530315) 530315..530497 + 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
P1705_RS02505 (530490) 530490..530777 - 288 WP_001541332.1 transcriptional regulator RtsB -
P1705_RS02510 (530774) 530774..531649 - 876 WP_000921676.1 AraC family transcriptional regulator -
P1705_RS02515 (531915) 531915..532136 - 222 WP_001576552.1 hypothetical protein -
P1705_RS02520 (532453) 532453..532746 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1705_RS02525 (532743) 532743..533234 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P1705_RS02530 (533482) 533482..534234 - 753 WP_283903117.1 non-specific acid phosphatase -
P1705_RS02535 (534334) 534334..534411 - 78 Protein_460 porin family protein -
P1705_RS02540 (534791) 534791..534865 + 75 Protein_461 helix-turn-helix domain-containing protein -
P1705_RS02550 (535136) 535136..535711 - 576 WP_001188509.1 transcriptional regulator -
P1705_RS02555 (535748) 535748..537451 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P1705_RS02560 (537427) 537427..537774 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T274644 WP_000626100.1 NZ_CP120322:532743-533234 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT274644 WP_001110452.1 NZ_CP120322:532453-532746 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References