Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4219635..4220416 Replicon chromosome
Accession NZ_CP120318
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_2_2022

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P1703_RS20725 Protein ID WP_000626100.1
Coordinates 4219635..4220126 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1703_RS20730 Protein ID WP_001110452.1
Coordinates 4220123..4220416 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1703_RS20690 (4215095) 4215095..4215442 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
P1703_RS20695 (4215418) 4215418..4217121 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P1703_RS20700 (4217158) 4217158..4217733 + 576 WP_001188509.1 transcriptional regulator -
P1703_RS20710 (4218004) 4218004..4218078 - 75 Protein_4046 helix-turn-helix domain-containing protein -
P1703_RS20715 (4218458) 4218458..4218535 + 78 Protein_4047 porin family protein -
P1703_RS20720 (4218635) 4218635..4219387 + 753 WP_000842433.1 non-specific acid phosphatase -
P1703_RS20725 (4219635) 4219635..4220126 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P1703_RS20730 (4220123) 4220123..4220416 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1703_RS20735 (4220733) 4220733..4220954 + 222 WP_001576552.1 hypothetical protein -
P1703_RS20740 (4221220) 4221220..4222095 + 876 WP_000921676.1 AraC family transcriptional regulator -
P1703_RS20745 (4222092) 4222092..4222379 + 288 WP_001541332.1 transcriptional regulator RtsB -
P1703_RS20750 (4222372) 4222372..4222680 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
P1703_RS20755 (4222679) 4222679..4222927 + 249 Protein_4055 Ig-like domain-containing protein -
P1703_RS20760 (4223039) 4223039..4223170 + 132 Protein_4056 hypothetical protein -
P1703_RS20765 (4223464) 4223464..4224369 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T274638 WP_000626100.1 NZ_CP120318:c4220126-4219635 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT274638 WP_001110452.1 NZ_CP120318:c4220416-4220123 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References