Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3445804..3446424 Replicon chromosome
Accession NZ_CP120318
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_2_2022

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1703_RS17065 Protein ID WP_001280991.1
Coordinates 3446206..3446424 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1703_RS17060 Protein ID WP_000344807.1
Coordinates 3445804..3446178 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1703_RS17050 (3440943) 3440943..3442136 + 1194 WP_283902913.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1703_RS17055 (3442159) 3442159..3445308 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1703_RS17060 (3445804) 3445804..3446178 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1703_RS17065 (3446206) 3446206..3446424 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1703_RS17070 (3446603) 3446603..3447154 + 552 WP_001278793.1 maltose O-acetyltransferase -
P1703_RS17075 (3447272) 3447272..3447742 + 471 WP_000136183.1 YlaC family protein -
P1703_RS17080 (3447798) 3447798..3447938 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1703_RS17085 (3447944) 3447944..3448204 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1703_RS17090 (3448429) 3448429..3449979 + 1551 WP_000213140.1 EAL domain-containing protein -
P1703_RS17100 (3450210) 3450210..3450599 + 390 WP_000961287.1 MGMT family protein -
P1703_RS17105 (3450632) 3450632..3451201 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274632 WP_001280991.1 NZ_CP120318:3446206-3446424 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274632 WP_000344807.1 NZ_CP120318:3445804-3446178 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References