Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4219628..4220409 Replicon chromosome
Accession NZ_CP120315
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_3_2022

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P1824_RS20730 Protein ID WP_000626100.1
Coordinates 4219628..4220119 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1824_RS20735 Protein ID WP_001110452.1
Coordinates 4220116..4220409 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1824_RS20695 (4215088) 4215088..4215435 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
P1824_RS20700 (4215411) 4215411..4217114 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P1824_RS20705 (4217151) 4217151..4217726 + 576 WP_001188509.1 transcriptional regulator -
P1824_RS20715 (4217997) 4217997..4218071 - 75 Protein_4047 helix-turn-helix domain-containing protein -
P1824_RS20720 (4218451) 4218451..4218528 + 78 Protein_4048 porin family protein -
P1824_RS20725 (4218628) 4218628..4219380 + 753 WP_000842433.1 non-specific acid phosphatase -
P1824_RS20730 (4219628) 4219628..4220119 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P1824_RS20735 (4220116) 4220116..4220409 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1824_RS20740 (4220726) 4220726..4220947 + 222 WP_001576552.1 hypothetical protein -
P1824_RS20745 (4221213) 4221213..4222088 + 876 WP_000921676.1 AraC family transcriptional regulator -
P1824_RS20750 (4222085) 4222085..4222372 + 288 WP_001541332.1 transcriptional regulator RtsB -
P1824_RS20755 (4222365) 4222365..4222673 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
P1824_RS20760 (4222672) 4222672..4222920 + 249 Protein_4056 Ig-like domain-containing protein -
P1824_RS20765 (4223032) 4223032..4223163 + 132 Protein_4057 hypothetical protein -
P1824_RS20770 (4223457) 4223457..4224362 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T274617 WP_000626100.1 NZ_CP120315:c4220119-4219628 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT274617 WP_001110452.1 NZ_CP120315:c4220409-4220116 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References