Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4021327..4021903 Replicon chromosome
Accession NZ_CP120315
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_3_2022

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag P1824_RS19720 Protein ID WP_001131963.1
Coordinates 4021616..4021903 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag P1824_RS19715 Protein ID WP_000063142.1
Coordinates 4021327..4021629 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1824_RS19700 (4017837) 4017837..4019987 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
P1824_RS19705 (4020082) 4020082..4020285 + 204 WP_000460616.1 YbdD/YjiX family protein -
P1824_RS19710 (4020296) 4020296..4021252 + 957 WP_000187843.1 GTPase -
P1824_RS19715 (4021327) 4021327..4021629 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
P1824_RS19720 (4021616) 4021616..4021903 - 288 WP_001131963.1 BrnT family toxin Toxin
P1824_RS19725 (4022341) 4022341..4024182 + 1842 WP_000974637.1 nuclease-related domain-containing DEAD/DEAH box helicase -
P1824_RS19730 (4024795) 4024795..4025370 + 576 WP_000593784.1 restriction endonuclease subunit S -
P1824_RS19735 (4025881) 4025881..4026627 + 747 WP_239642453.1 N-6 DNA methylase -
P1824_RS19740 (4026659) 4026659..4026793 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T274614 WP_001131963.1 NZ_CP120315:c4021903-4021616 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT274614 WP_000063142.1 NZ_CP120315:c4021629-4021327 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References