Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 2191858..2192443 Replicon chromosome
Accession NZ_CP120212
Organism Agrobacterium leguminum strain CFBP4996

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CFBP4996_RS24535 Protein ID WP_080853461.1
Coordinates 2192141..2192443 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A546W9H2
Locus tag CFBP4996_RS24530 Protein ID WP_003521755.1
Coordinates 2191858..2192148 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP4996_RS24510 (CFBP4996_24510) 2187958..2188968 + 1011 WP_080853465.1 iron-siderophore ABC transporter substrate-binding protein -
CFBP4996_RS24515 (CFBP4996_24515) 2188965..2190008 + 1044 WP_080853464.1 iron ABC transporter permease -
CFBP4996_RS24520 (CFBP4996_24520) 2190005..2191045 + 1041 WP_080853463.1 iron chelate uptake ABC transporter family permease subunit -
CFBP4996_RS24525 (CFBP4996_24525) 2191042..2191857 + 816 WP_080853462.1 ABC transporter ATP-binding protein -
CFBP4996_RS24530 (CFBP4996_24530) 2191858..2192148 - 291 WP_003521755.1 putative addiction module antidote protein Antitoxin
CFBP4996_RS24535 (CFBP4996_24535) 2192141..2192443 - 303 WP_080853461.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP4996_RS24540 (CFBP4996_24540) 2192605..2193477 - 873 WP_080853460.1 helix-turn-helix transcriptional regulator -
CFBP4996_RS24545 (CFBP4996_24545) 2193612..2194826 + 1215 WP_080853459.1 amino acid ABC transporter substrate-binding protein -
CFBP4996_RS24550 (CFBP4996_24550) 2194897..2195769 + 873 WP_080853458.1 branched-chain amino acid ABC transporter permease -
CFBP4996_RS24555 (CFBP4996_24555) 2195766..2196674 + 909 WP_003521750.1 branched-chain amino acid ABC transporter permease -
CFBP4996_RS24560 (CFBP4996_24560) 2196671..2197399 + 729 WP_080853457.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(39-91)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11084.59 Da        Isoelectric Point: 8.9323

>T274594 WP_080853461.1 NZ_CP120212:c2192443-2192141 [Agrobacterium leguminum]
MQLKQSATFQKWFGKLKDERGKALITSRLNRLSFGHAGDVAPVGEGVSELRIHYGPGYRIYFVRSGDVVIVLLCGGDKST
QEKDIKAAKQIAAQWSDDDD

Download         Length: 303 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10395.75 Da        Isoelectric Point: 5.0873

>AT274594 WP_003521755.1 NZ_CP120212:c2192148-2191858 [Agrobacterium leguminum]
MIEKFTNFDPAEHLKSDEAIEVFLEDAFATNDAAYIANALGVIARAKGMTQVARETGLAREHLYKSLSEAGNPTLETTIA
VLNSLGFQLTSKHKAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A546W9H2

References