Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3341544..3342177 Replicon chromosome
Accession NZ_CP120208
Organism Weizmannia coagulans strain HOM5301

Toxin (Protein)


Gene name mazF Uniprot ID G2TIM0
Locus tag O2602_RS15975 Protein ID WP_013860680.1
Coordinates 3341544..3341894 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G2TIL9
Locus tag O2602_RS15980 Protein ID WP_014096808.1
Coordinates 3341899..3342177 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2602_RS15940 3336799..3337578 - 780 WP_014096815.1 RNA polymerase sigma factor SigB -
O2602_RS15945 3337556..3338026 - 471 WP_026684337.1 anti-sigma B factor RsbW -
O2602_RS15950 3338030..3338365 - 336 WP_026104587.1 anti-sigma factor antagonist -
O2602_RS15955 3338435..3339445 - 1011 WP_276210650.1 PP2C family protein-serine/threonine phosphatase -
O2602_RS15960 3339460..3339861 - 402 WP_014096811.1 anti-sigma regulatory factor -
O2602_RS15965 3339866..3340222 - 357 WP_014096810.1 STAS domain-containing protein -
O2602_RS15970 3340226..3341053 - 828 WP_014096809.1 RsbT co-antagonist protein RsbRA -
O2602_RS15975 3341544..3341894 - 351 WP_013860680.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O2602_RS15980 3341899..3342177 - 279 WP_014096808.1 hypothetical protein Antitoxin
O2602_RS15985 3342330..3343481 - 1152 WP_276210651.1 alanine racemase -
O2602_RS15990 3343682..3344698 - 1017 WP_014096806.1 outer membrane lipoprotein carrier protein LolA -
O2602_RS15995 3344839..3345189 - 351 WP_276210652.1 holo-ACP synthase -
O2602_RS16000 3345470..3346069 + 600 WP_276210653.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12968.01 Da        Isoelectric Point: 4.8998

>T274587 WP_013860680.1 NZ_CP120208:c3341894-3341544 [Weizmannia coagulans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGLERDSVILLEQI
RTIDKQRLTDKITHLDEEVMEKIDDALQISLGLVEF

Download         Length: 351 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10633.19 Da        Isoelectric Point: 5.2204

>AT274587 WP_014096808.1 NZ_CP120208:c3342177-3341899 [Weizmannia coagulans]
VSEPISTEILVRLPQQLLTELDGFAETENMNRNELIYRATKMYLKERKKRQIRETMRRGYMEMAKINLAIASEAIQAEYE
AEHTVESLVSGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4BYJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4BX66

References