Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48630..49273 Replicon plasmid p514780
Accession NZ_CP119987
Organism Salmonella enterica strain CRIN514780

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag P2V97_RS23245 Protein ID WP_023994137.1
Coordinates 48630..49046 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag P2V97_RS23250 Protein ID WP_023994136.1
Coordinates 49043..49273 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2V97_RS23215 (44110) 44110..44901 + 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -
P2V97_RS23220 (44929) 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
P2V97_RS23225 (45896) 45896..46486 + 591 WP_023994140.1 hypothetical protein -
P2V97_RS23230 (46552) 46552..46764 + 213 WP_023994139.1 FaeA/PapI family transcriptional regulator -
P2V97_RS23235 (47025) 47025..47186 + 162 WP_001816720.1 hypothetical protein -
P2V97_RS23240 (47212) 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
P2V97_RS23245 (48630) 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
P2V97_RS23250 (49043) 49043..49273 - 231 WP_023994136.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P2V97_RS23255 (49897) 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
P2V97_RS23260 (50117) 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
P2V97_RS23265 (50424) 50424..50714 + 291 WP_023994133.1 hypothetical protein -
P2V97_RS23270 (50711) 50711..50986 + 276 Protein_59 3'-5' exonuclease -
P2V97_RS23275 (51057) 51057..51173 + 117 Protein_60 hypothetical protein -
P2V97_RS23280 (51163) 51163..51878 - 716 Protein_61 transposase -
P2V97_RS23285 (53160) 53160..53696 + 537 WP_023994130.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / floR / aph(4)-Ia / aac(3)-IVa / aph(3')-Ia faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..312164 312164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15123.58 Da        Isoelectric Point: 8.5291

>T274580 WP_023994137.1 NZ_CP119987:c49046-48630 [Salmonella enterica]
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR

Download         Length: 417 bp

>T274580 NZ_CP119987:c49046-48630 [Salmonella enterica]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8650.75 Da        Isoelectric Point: 4.5881

>AT274580 WP_023994136.1 NZ_CP119987:c49273-49043 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT274580 NZ_CP119987:c49273-49043 [Salmonella enterica]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References