Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2431436..2432267 Replicon chromosome
Accession NC_017641
Organism Escherichia coli UMNK88

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag UMNK88_RS12675 Protein ID WP_000854814.1
Coordinates 2431893..2432267 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag UMNK88_RS12670 Protein ID WP_001285585.1
Coordinates 2431436..2431804 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UMNK88_RS12635 2426664..2427734 + 1071 WP_000102643.1 patatin-like phospholipase family protein -
UMNK88_RS12640 2427870..2428553 + 684 WP_015675250.1 hypothetical protein -
UMNK88_RS12645 2428569..2428979 + 411 WP_000846713.1 hypothetical protein -
UMNK88_RS12650 2429200..2430021 + 822 WP_001234530.1 DUF945 domain-containing protein -
UMNK88_RS12655 2430103..2430582 + 480 WP_000860076.1 antirestriction protein -
UMNK88_RS32430 2430598..2431075 + 478 Protein_2412 RadC family protein -
UMNK88_RS12665 2431150..2431362 + 213 WP_001401366.1 DUF987 domain-containing protein -
UMNK88_RS12670 2431436..2431804 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
UMNK88_RS12675 2431893..2432267 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
UMNK88_RS12680 2432264..2432458 + 195 WP_000988602.1 hypothetical protein -
UMNK88_RS34200 2432471..2432584 + 114 WP_001161660.1 DUF957 domain-containing protein -
UMNK88_RS30665 2432873..2433001 - 129 Protein_2418 transposase domain-containing protein -
UMNK88_RS12690 2433073..2433255 + 183 WP_001016348.1 hypothetical protein -
UMNK88_RS12695 2433356..2433685 - 330 WP_000450409.1 DUF496 family protein -
UMNK88_RS12700 2433857..2434915 - 1059 WP_001200891.1 FUSC family protein -
UMNK88_RS12705 2435113..2435586 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
UMNK88_RS12710 2435705..2436871 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T27457 WP_000854814.1 NC_017641:2431893-2432267 [Escherichia coli UMNK88]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27457 NC_017641:2431893-2432267 [Escherichia coli UMNK88]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT27457 WP_001285585.1 NC_017641:2431436-2431804 [Escherichia coli UMNK88]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT27457 NC_017641:2431436-2431804 [Escherichia coli UMNK88]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References