Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 443342..443858 Replicon chromosome
Accession NZ_CP119984
Organism Salmonella enterica strain CRIN508879

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag P2W29_RS02105 Protein ID WP_023993574.1
Coordinates 443574..443858 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag P2W29_RS02100 Protein ID WP_023993575.1
Coordinates 443342..443584 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W29_RS02080 (438362) 438362..439495 + 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -
P2W29_RS02085 (439479) 439479..440597 + 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P2W29_RS02090 (440594) 440594..441334 + 741 WP_023993577.1 KDGP aldolase family protein -
P2W29_RS02095 (441351) 441351..443264 + 1914 WP_023993576.1 BglG family transcription antiterminator -
P2W29_RS02100 (443342) 443342..443584 + 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P2W29_RS02105 (443574) 443574..443858 + 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P2W29_RS02110 (443862) 443862..444326 - 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P2W29_RS02115 (444543) 444543..446681 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P2W29_RS02120 (447090) 447090..448742 - 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T274539 WP_023993574.1 NZ_CP119984:443574-443858 [Salmonella enterica]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT274539 WP_023993575.1 NZ_CP119984:443342-443584 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References