Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4297632..4298392 Replicon chromosome
Accession NZ_CP119982
Organism Salmonella enterica strain CRIN541822

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P2V99_RS20900 Protein ID WP_000533909.1
Coordinates 4297632..4298117 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P2V99_RS20905 Protein ID WP_000965886.1
Coordinates 4298105..4298392 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2V99_RS20870 (4292703) 4292703..4293365 + 663 WP_000747548.1 OmpA family lipoprotein -
P2V99_RS20875 (4293584) 4293584..4294558 + 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
P2V99_RS20880 (4294608) 4294608..4295318 - 711 WP_000190524.1 DUF3053 domain-containing protein -
P2V99_RS20885 (4295757) 4295757..4296047 + 291 WP_000455790.1 HTH-type transcriptional regulator -
P2V99_RS20890 (4296335) 4296335..4296547 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P2V99_RS20895 (4296721) 4296721..4297260 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
P2V99_RS20900 (4297632) 4297632..4298117 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P2V99_RS20905 (4298105) 4298105..4298392 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P2V99_RS20910 (4298558) 4298558..4299116 - 559 Protein_4078 cysteine hydrolase -
P2V99_RS20915 (4299205) 4299205..4300407 - 1203 WP_023201740.1 MFS transporter -
P2V99_RS20920 (4300492) 4300492..4301142 + 651 WP_023993641.1 GntR family transcriptional regulator -
P2V99_RS20925 (4301261) 4301261..4301689 - 429 Protein_4081 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T274527 WP_000533909.1 NZ_CP119982:c4298117-4297632 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT274527 WP_000965886.1 NZ_CP119982:c4298392-4298105 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References