Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3487818..3488632 Replicon chromosome
Accession NZ_CP119982
Organism Salmonella enterica strain CRIN541822

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag P2V99_RS17015 Protein ID WP_023994249.1
Coordinates 3488105..3488632 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P2V99_RS17010 Protein ID WP_000855694.1
Coordinates 3487818..3488108 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2V99_RS16980 (3483768) 3483768..3484418 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
P2V99_RS16985 (3484874) 3484874..3485317 + 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P2V99_RS16990 (3485749) 3485749..3486198 + 450 WP_000381612.1 membrane protein -
P2V99_RS16995 (3486183) 3486183..3486530 + 348 WP_001669174.1 DUF1493 family protein -
P2V99_RS17000 (3486803) 3486803..3487129 - 327 WP_000393300.1 hypothetical protein -
P2V99_RS17005 (3487370) 3487370..3487548 + 179 Protein_3316 IS3 family transposase -
P2V99_RS17010 (3487818) 3487818..3488108 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P2V99_RS17015 (3488105) 3488105..3488632 + 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
P2V99_RS17020 (3488705) 3488705..3488922 - 218 Protein_3319 IS5/IS1182 family transposase -
P2V99_RS17025 (3489257) 3489257..3489913 + 657 WP_000420451.1 protein-serine/threonine phosphatase -
P2V99_RS17030 (3490084) 3490084..3490605 - 522 WP_023994250.1 hypothetical protein -
P2V99_RS17035 (3490764) 3490764..3493331 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3488705..3488845 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T274524 WP_023994249.1 NZ_CP119982:3488105-3488632 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274524 WP_000855694.1 NZ_CP119982:3487818-3488108 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References