Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109741..1110361 Replicon chromosome
Accession NZ_CP119982
Organism Salmonella enterica strain CRIN541822

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P2V99_RS05205 Protein ID WP_001280991.1
Coordinates 1109741..1109959 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P2V99_RS05210 Protein ID WP_000344807.1
Coordinates 1109987..1110361 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2V99_RS05165 (1104964) 1104964..1105533 + 570 WP_000779802.1 YbaY family lipoprotein -
P2V99_RS05170 (1105566) 1105566..1105955 - 390 WP_000961285.1 MGMT family protein -
P2V99_RS05180 (1106186) 1106186..1107736 - 1551 WP_000213140.1 EAL domain-containing protein -
P2V99_RS05185 (1107961) 1107961..1108221 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P2V99_RS05190 (1108227) 1108227..1108367 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P2V99_RS05195 (1108423) 1108423..1108893 - 471 WP_000136183.1 YlaC family protein -
P2V99_RS05200 (1109011) 1109011..1109562 - 552 WP_001278793.1 maltose O-acetyltransferase -
P2V99_RS05205 (1109741) 1109741..1109959 - 219 WP_001280991.1 HHA domain-containing protein Toxin
P2V99_RS05210 (1109987) 1109987..1110361 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P2V99_RS05215 (1110857) 1110857..1114006 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P2V99_RS05220 (1114029) 1114029..1115222 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274518 WP_001280991.1 NZ_CP119982:c1109959-1109741 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274518 WP_000344807.1 NZ_CP119982:c1110361-1109987 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References