Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 23380..24014 Replicon plasmid pOB3b_01
Accession NZ_CP119870
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A6FHD3
Locus tag P3C36_RS21470 Protein ID WP_003612723.1
Coordinates 23380..23781 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A6FGH4
Locus tag P3C36_RS21475 Protein ID WP_003612725.1
Coordinates 23778..24014 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS21460 21237..22157 + 921 WP_003612721.1 DNA-binding response regulator -
P3C36_RS21465 22264..23322 + 1059 WP_003612722.1 DUF2252 family protein -
P3C36_RS21470 23380..23781 - 402 WP_003612723.1 type II toxin-antitoxin system VapC family toxin Toxin
P3C36_RS21475 23778..24014 - 237 WP_003612725.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..285789 285789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13934.03 Da        Isoelectric Point: 6.7108

>T274484 WP_003612723.1 NZ_CP119870:c23781-23380 [Methylosinus trichosporium OB3b]
MTRYLLDTNIVSDLIRNPRGRVAAHIAHVGEANVCTSVIVAAELRYGCAKSGSKRLSAAVESLLGELAVLALEGPAAAEY
GAIRAGLERRGTPIGGNDLLIAAHALAIDATVVTANMDEFARVEGLKVQNWLA

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8935.25 Da        Isoelectric Point: 4.5447

>AT274484 WP_003612725.1 NZ_CP119870:c24014-23778 [Methylosinus trichosporium OB3b]
MGEARHVKLFRNGRNQAVRIPVEFELPGDEAIMRREGDRLVLEPTRKRGLLGLLETMEPIDEAFPEIEDQPPAPEPIF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FHD3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FGH4

References