274481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3148966..3149995 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag P3C36_RS15125 Protein ID WP_244441355.1
Coordinates 3149555..3149995 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A1A6FRX6
Locus tag P3C36_RS15120 Protein ID WP_003614574.1
Coordinates 3148966..3149430 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS15105 3145742..3147538 - 1797 WP_003614570.1 DNA helicase RecQ -
P3C36_RS15110 3147584..3147862 - 279 WP_003614571.1 hypothetical protein -
P3C36_RS15115 3147912..3148754 - 843 WP_003614572.1 hypothetical protein -
P3C36_RS15120 3148966..3149430 + 465 WP_003614574.1 helix-turn-helix domain-containing protein Antitoxin
P3C36_RS15125 3149555..3149995 + 441 WP_244441355.1 PIN domain-containing protein Toxin
P3C36_RS15130 3150228..3150587 - 360 WP_003614858.1 response regulator -
P3C36_RS15135 3150677..3151186 - 510 WP_283472100.1 HWE histidine kinase domain-containing protein -
P3C36_RS15140 3151161..3152774 - 1614 WP_283470244.1 PAS domain-containing protein -
P3C36_RS15145 3152910..3153950 + 1041 WP_003614863.1 signal recognition particle-docking protein FtsY -
P3C36_RS15150 3153947..3154564 + 618 WP_003614865.1 septation protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Helix-turn-helix domain, group 17

(81-128)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16385.79 Da        Isoelectric Point: 5.1962

>T274481 WP_244441355.1 NZ_CP119869:3149555-3149995 [Methylosinus trichosporium OB3b]
IEALLRNEPHRDRSLLERTRDRMDQHVRDYLVTGYEPLIPSLVLPDMNDRHVLAAAIVGRCDVIVTQNLKHFPETALAPL
DIDAQHPDEFLCNQLDLAPGIFCAAVRKVCARLKNPLYSVDDYLANLTRQGLVGAASELEQFSGLI

Download         Length: 441 bp

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17117.60 Da        Isoelectric Point: 7.4709

>AT274481 WP_003614574.1 NZ_CP119869:3148966-3149430 [Methylosinus trichosporium OB3b]
MTALAHRQLPPTAQDAAIARTSGQRLSRFARSNRSLSLRITDAEQEQPIELPAGAVSLLMDILEAMAAGRGVTLIPENAE
LTSVQAADILNVSRPFLIGLLDSKAIPHHKVGKHRRIRMEDVMAYKERIDRERETVLDQLVADAQEHDMGYSRK

Download         Length: 465 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FRX6

References