Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2677560..2678332 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1A6FSR2
Locus tag P3C36_RS12870 Protein ID WP_065083547.1
Coordinates 2677560..2678054 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1A6FRN5
Locus tag P3C36_RS12875 Protein ID WP_003609827.1
Coordinates 2678051..2678332 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS12855 2672864..2673350 - 487 Protein_2518 peroxiredoxin -
P3C36_RS12860 2673528..2677067 + 3540 WP_003609825.1 AsmA-like C-terminal region-containing protein -
P3C36_RS12865 2677175..2677513 + 339 WP_024749350.1 septum formation initiator family protein -
P3C36_RS12870 2677560..2678054 - 495 WP_065083547.1 GNAT family N-acetyltransferase Toxin
P3C36_RS12875 2678051..2678332 - 282 WP_003609827.1 DUF1778 domain-containing protein Antitoxin
P3C36_RS12880 2678450..2679745 + 1296 WP_003609828.1 dihydroorotase -
P3C36_RS12885 2679941..2682286 + 2346 WP_003609830.1 TonB-dependent receptor -
P3C36_RS12890 2682317..2682496 - 180 WP_155931222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-141)

Antitoxin

Vibrio phage ICP1, Orf50

(3-93)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17593.28 Da        Isoelectric Point: 6.8716

>T274480 WP_065083547.1 NZ_CP119869:c2678054-2677560 [Methylosinus trichosporium OB3b]
MTLTAPEPIDESHIVNDFDSGVPVLDDWLMRRARANQASGASRAYVICEDRRVVGYYALAAGAVEISNATGRLRRNMPDP
VPIAVLGRLAIHRGFQGNGLGRALVRDAGQRVLQAADIIGIRGILVHVLSPEAEAFYHALGLEASALQPMTLMATLADLR
AALI

Download         Length: 495 bp

>T274480 NZ_CP119869:c2678054-2677560 [Methylosinus trichosporium OB3b]
ATGACGCTCACTGCTCCCGAGCCGATCGATGAATCGCACATCGTCAATGACTTCGACTCTGGCGTTCCGGTCCTCGACGA
TTGGCTGATGCGCCGCGCCCGGGCGAACCAGGCGAGCGGCGCATCGCGCGCATATGTGATTTGCGAGGACCGGCGTGTCG
TCGGCTATTATGCGCTCGCCGCCGGCGCCGTCGAAATCTCGAATGCGACAGGACGCCTTCGCCGCAACATGCCCGATCCT
GTCCCGATCGCCGTGCTGGGACGATTGGCGATCCACCGCGGCTTCCAGGGAAACGGCCTCGGTCGCGCTCTCGTGCGGGA
CGCGGGGCAGCGTGTGCTGCAAGCCGCCGATATTATAGGGATTCGTGGAATTCTCGTTCACGTGCTCTCACCGGAAGCAG
AGGCTTTTTATCACGCCCTCGGCCTAGAGGCGTCGGCCTTGCAGCCCATGACGCTGATGGCGACGTTGGCCGATCTGCGC
GCAGCGTTGATTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10553.20 Da        Isoelectric Point: 11.0151

>AT274480 WP_003609827.1 NZ_CP119869:c2678332-2678051 [Methylosinus trichosporium OB3b]
MTVKPQAKRDTLNVRVKPEDRSLIDRAARLLGKSRADFLLESARRAAHDVLLDQTLFKVSPQVYGEFIARLDAPPAPNER
LRRTMATPAAWEK

Download         Length: 282 bp

>AT274480 NZ_CP119869:c2678332-2678051 [Methylosinus trichosporium OB3b]
ATGACTGTCAAACCACAAGCGAAGCGCGACACGCTCAATGTGCGGGTCAAGCCCGAGGATCGCAGCCTCATCGACCGCGC
AGCGCGGCTGCTGGGCAAGAGCCGCGCCGATTTTCTGCTCGAATCTGCGCGGCGGGCGGCGCATGACGTTCTGCTGGATC
AGACGCTCTTCAAAGTCAGTCCACAAGTCTACGGCGAGTTCATCGCGAGGCTCGACGCGCCGCCTGCGCCGAATGAGAGG
CTTCGCCGCACGATGGCGACTCCGGCGGCGTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FSR2

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FRN5

References