Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-YefM
Location 2264291..2264796 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1A6FN25
Locus tag P3C36_RS10870 Protein ID WP_003613166.1
Coordinates 2264291..2264545 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A1A6FKR2
Locus tag P3C36_RS10875 Protein ID WP_003613168.1
Coordinates 2264542..2264796 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS10850 2260602..2261120 - 519 WP_003613161.1 DUF1269 domain-containing protein -
P3C36_RS10855 2261256..2262806 - 1551 WP_003613162.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
P3C36_RS10860 2262935..2263456 + 522 WP_003613164.1 hypothetical protein -
P3C36_RS10865 2263485..2264219 + 735 WP_003613165.1 SDR family oxidoreductase -
P3C36_RS10870 2264291..2264545 - 255 WP_003613166.1 Txe/YoeB family addiction module toxin Toxin
P3C36_RS10875 2264542..2264796 - 255 WP_003613168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
P3C36_RS10880 2264988..2266163 - 1176 WP_024749735.1 IS4 family transposase -
P3C36_RS10885 2266302..2267222 - 921 WP_003610338.1 neutral zinc metallopeptidase -
P3C36_RS10890 2267219..2268118 - 900 WP_003610339.1 TIGR00282 family metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10070.61 Da        Isoelectric Point: 8.4811

>T274479 WP_003613166.1 NZ_CP119869:c2264545-2264291 [Methylosinus trichosporium OB3b]
MKLVFAEQAWEDYLYWQAQDPKIVERINQLVKECLQTPFSGTGKPEPLRGGLRGWWSRRITLEHRLVYRVEGESLMIAQC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9278.43 Da        Isoelectric Point: 5.7251

>AT274479 WP_003613168.1 NZ_CP119869:c2264796-2264542 [Methylosinus trichosporium OB3b]
MRSTSYSDLRKNLAATLDRVTADHEPVVITRDRGKPAAVLISLEDFASYEETAHLLKSPRNAERLQAAIEALDAGEGKER
KLAE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FN25

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FKR2

References