Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 307471..308354 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag P3C36_RS01420 Protein ID WP_283471160.1
Coordinates 307743..308354 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A1A6FQL2
Locus tag P3C36_RS01415 Protein ID WP_003608948.1
Coordinates 307471..307746 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS01390 303212..304198 - 987 WP_003608940.1 ferrochelatase -
P3C36_RS01395 304195..305007 - 813 WP_003608942.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
P3C36_RS01400 305042..305167 - 126 WP_274541221.1 hypothetical protein -
P3C36_RS01405 305365..305937 - 573 WP_003608944.1 L,D-transpeptidase -
P3C36_RS01410 306095..307318 + 1224 WP_003608946.1 alpha/beta hydrolase -
P3C36_RS01415 307471..307746 + 276 WP_003608948.1 DUF1778 domain-containing protein Antitoxin
P3C36_RS01420 307743..308354 + 612 WP_283471160.1 GNAT family N-acetyltransferase Toxin
P3C36_RS01425 308971..309456 - 486 WP_155931266.1 hypothetical protein -
P3C36_RS01430 309973..310950 + 978 WP_003608953.1 methenyltetrahydromethanopterin cyclohydrolase -
P3C36_RS01435 310904..311869 + 966 WP_283471163.1 RimK family alpha-L-glutamate ligase -
P3C36_RS01440 311862..312725 + 864 WP_003608957.1 triphosphoribosyl-dephospho-CoA synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 142155..342228 200073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-119)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22388.85 Da        Isoelectric Point: 10.2082

>T274476 WP_283471160.1 NZ_CP119869:307743-308354 [Methylosinus trichosporium OB3b]
MTALEWEEVSLGKIHDRNAFHCGEDHLDTYLKRYARQNHESGGAKCFVAAARDAPTRVLGFYTLSPASIEFARAPAVATR
GLGRYEVPVYRLGRLAVDRSVQGRGLGGRLLLRAAERCMAVAQQVGGVALLIDAKTEMVAEWVRKLRGTTSPRCAALAHP
ALRRGGRSGEARGAMMLSNVTYARRMRPFFLIQVEVDYSEVLI

Download         Length: 612 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10167.76 Da        Isoelectric Point: 8.8518

>AT274476 WP_003608948.1 NZ_CP119869:307471-307746 [Methylosinus trichosporium OB3b]
MPREHAETGRVELRLKPEDKAVLARAAALERLDLTSFILRAALPRAQDVIAQSERLKLSERDSLRVLDLLENPPAPTERL
TRAAKGGFVLE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FQL2

References