Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 931104..931729 Replicon chromosome
Accession NZ_CP119863
Organism Agrobacterium fabrum strain NT1RE

Toxin (Protein)


Gene name mazF Uniprot ID Q7D0B1
Locus tag NT1RE_RS04665 Protein ID WP_006311244.1
Coordinates 931370..931729 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q7D0B2
Locus tag NT1RE_RS04660 Protein ID WP_010971270.1
Coordinates 931104..931370 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT1RE_RS04630 (NT1RE_04630) 926278..926613 - 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin -
NT1RE_RS04635 (NT1RE_04635) 926610..926885 - 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
NT1RE_RS04640 (NT1RE_04640) 926993..927601 + 609 WP_010971267.1 class I SAM-dependent methyltransferase -
NT1RE_RS04645 (NT1RE_04645) 927777..930362 + 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
NT1RE_RS04650 (NT1RE_04650) 930359..930781 + 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
NT1RE_RS04655 (NT1RE_04655) 930834..931034 + 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
NT1RE_RS04660 (NT1RE_04660) 931104..931370 + 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NT1RE_RS04665 (NT1RE_04665) 931370..931729 + 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NT1RE_RS04670 (NT1RE_04670) 931737..931985 - 249 WP_006311245.1 hypothetical protein -
NT1RE_RS04675 (NT1RE_04675) 932164..933552 + 1389 WP_169539085.1 MFS transporter -
NT1RE_RS04680 (NT1RE_04680) 933631..933804 - 174 WP_010971273.1 hypothetical protein -
NT1RE_RS04685 (NT1RE_04685) 933873..935591 - 1719 WP_035256424.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12857.04 Da        Isoelectric Point: 8.2782

>T274474 WP_006311244.1 NZ_CP119863:931370-931729 [Agrobacterium fabrum]
MVRNQIPKRGDVYLVDLNPVVGSEIKDEHRCVVITPREINAVGLCLVVPVTTGGMFTRKAGLAVNISGHKTTGVALCNQV
RSMDIVARVAQKKAKYIETLDDATIDEIAGRVISMIDPA

Download         Length: 360 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9423.02 Da        Isoelectric Point: 5.1106

>AT274474 WP_010971270.1 NZ_CP119863:931104-931370 [Agrobacterium fabrum]
MTVTTKIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRLEKKRFTLAELLDGAEEVAALNARERAWDTA
PPVGKEAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B1

Antitoxin

Source ID Structure
AlphaFold DB Q7D0B2

References