Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 926278..926885 Replicon chromosome
Accession NZ_CP119863
Organism Agrobacterium fabrum strain NT1RE

Toxin (Protein)


Gene name relE Uniprot ID Q7D0B7
Locus tag NT1RE_RS04630 Protein ID WP_010971265.1
Coordinates 926278..926613 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A9CJP8
Locus tag NT1RE_RS04635 Protein ID WP_010971266.1
Coordinates 926610..926885 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT1RE_RS04615 (NT1RE_04615) 922383..924578 - 2196 WP_035256415.1 transglycosylase domain-containing protein -
NT1RE_RS04620 (NT1RE_04620) 924835..925314 + 480 WP_010971263.1 YcgN family cysteine cluster protein -
NT1RE_RS04625 (NT1RE_04625) 925426..926250 + 825 WP_010971264.1 class D beta-lactamase -
NT1RE_RS04630 (NT1RE_04630) 926278..926613 - 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin Toxin
NT1RE_RS04635 (NT1RE_04635) 926610..926885 - 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NT1RE_RS04640 (NT1RE_04640) 926993..927601 + 609 WP_010971267.1 class I SAM-dependent methyltransferase -
NT1RE_RS04645 (NT1RE_04645) 927777..930362 + 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
NT1RE_RS04650 (NT1RE_04650) 930359..930781 + 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
NT1RE_RS04655 (NT1RE_04655) 930834..931034 + 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
NT1RE_RS04660 (NT1RE_04660) 931104..931370 + 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
NT1RE_RS04665 (NT1RE_04665) 931370..931729 + 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(23-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-67)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12991.86 Da        Isoelectric Point: 10.0059

>T274473 WP_010971265.1 NZ_CP119863:c926613-926278 [Agrobacterium fabrum]
VTNKKDHGKDAALKRATLPRRSDFTKQFIKDWQRLNNSGRYDMVRLKEIMLLLIANGAPLPTQFRDHELTGDWRDHRECH
VGGDFLLIYTVDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9918.40 Da        Isoelectric Point: 6.3350

>AT274473 WP_010971266.1 NZ_CP119863:c926885-926610 [Agrobacterium fabrum]
MTANAYVRARIDQTLKDDATAVLDRLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAAGRNRFGTSE
ALFEALDAGKR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B7

Antitoxin

Source ID Structure
AlphaFold DB A9CJP8

References