274472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 672395..672875 Replicon chromosome
Accession NZ_CP119863
Organism Agrobacterium fabrum strain NT1RE

Toxin (Protein)


Gene name pasB Uniprot ID A9CK22
Locus tag NT1RE_RS03335 Protein ID WP_010971059.1
Coordinates 672395..672664 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A9CK21
Locus tag NT1RE_RS03340 Protein ID WP_010971060.1
Coordinates 672648..672875 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT1RE_RS03305 (NT1RE_03305) 667446..668222 - 777 WP_010971054.1 L,D-transpeptidase -
NT1RE_RS03310 (NT1RE_03310) 668461..669090 + 630 WP_010971055.1 DNA-3-methyladenine glycosylase I -
NT1RE_RS03315 (NT1RE_03315) 669087..669530 + 444 WP_010972617.1 hypothetical protein -
NT1RE_RS03320 (NT1RE_03320) 669556..670599 - 1044 WP_035256280.1 YeiH family protein -
NT1RE_RS03325 (NT1RE_03325) 670681..671598 + 918 WP_010971057.1 LysR family transcriptional regulator -
NT1RE_RS03330 (NT1RE_03330) 671624..672388 - 765 WP_010971058.1 hypothetical protein -
NT1RE_RS03335 (NT1RE_03335) 672395..672664 - 270 WP_010971059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NT1RE_RS03340 (NT1RE_03340) 672648..672875 - 228 WP_010971060.1 DUF6290 family protein Antitoxin
NT1RE_RS03345 (NT1RE_03345) 673032..674555 + 1524 WP_010971061.1 histidine--tRNA ligase -
NT1RE_RS03350 (NT1RE_03350) 674560..674928 + 369 WP_010971062.1 VOC family protein -
NT1RE_RS03355 (NT1RE_03355) 674945..676072 + 1128 WP_010971063.1 ATP phosphoribosyltransferase regulatory subunit -
NT1RE_RS03360 (NT1RE_03360) 676069..676761 + 693 WP_010971064.1 ATP phosphoribosyltransferase -
NT1RE_RS03365 (NT1RE_03365) 676826..677272 - 447 WP_006313161.1 DoxX family protein -
NT1RE_RS03370 (NT1RE_03370) 677428..677847 - 420 WP_230060738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(6-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10746.46 Da        Isoelectric Point: 9.9414

>T274472 WP_010971059.1 NZ_CP119863:c672664-672395 [Agrobacterium fabrum]
VIWTIEYHTLVQKEMRKINPEVRRRIRSFLHERLAALDDPRQIGATLQGSELGNFWRYRVGDYRIICDIQDQKLVVLVVE
IGHRREIYR

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8937.97 Da        Isoelectric Point: 4.7254

>AT274472 WP_010971060.1 NZ_CP119863:c672875-672648 [Agrobacterium fabrum]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRRIQRGESKIISAEEFWRDLDN

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9CK22

Antitoxin

Source ID Structure
AlphaFold DB A9CK21

References