Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4738898..4739514 Replicon chromosome
Accession NZ_CP119862
Organism Citrobacter sp. S171

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P2W74_RS22550 Protein ID WP_276293314.1
Coordinates 4738898..4739272 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P2W74_RS22555 Protein ID WP_192614423.1
Coordinates 4739272..4739514 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W74_RS22535 (4736398) 4736398..4737300 + 903 WP_276293312.1 formate dehydrogenase subunit beta -
P2W74_RS22540 (4737297) 4737297..4737932 + 636 WP_192613906.1 formate dehydrogenase cytochrome b556 subunit -
P2W74_RS22545 (4737929) 4737929..4738858 + 930 WP_276293313.1 formate dehydrogenase accessory protein FdhE -
P2W74_RS22550 (4738898) 4738898..4739272 - 375 WP_276293314.1 type II toxin-antitoxin system VapC family toxin Toxin
P2W74_RS22555 (4739272) 4739272..4739514 - 243 WP_192614423.1 CopG family transcriptional regulator Antitoxin
P2W74_RS22560 (4739720) 4739720..4740628 + 909 WP_276293315.1 alpha/beta hydrolase -
P2W74_RS22565 (4740810) 4740810..4741751 - 942 WP_203359406.1 fatty acid biosynthesis protein FabY -
P2W74_RS22570 (4741796) 4741796..4742233 - 438 WP_276293316.1 D-aminoacyl-tRNA deacylase -
P2W74_RS22575 (4742230) 4742230..4743102 - 873 WP_276293317.1 virulence factor BrkB family protein -
P2W74_RS22580 (4743096) 4743096..4743695 - 600 WP_203359408.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13735.88 Da        Isoelectric Point: 7.2022

>T274471 WP_276293314.1 NZ_CP119862:c4739272-4738898 [Citrobacter sp. S171]
MAKGSALFDTNILIDLFSGRGEAKQALDAWPPQNAISLITWMEVLVGARKYNQEHRTRVAMSAFNIIGVSQEIAERSVVL
RQDYGLKLPDAIILATAQIHRLELVTRNTKDFAGIPGVVTPYEL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9403.63 Da        Isoelectric Point: 4.2402

>AT274471 WP_192614423.1 NZ_CP119862:c4739514-4739272 [Citrobacter sp. S171]
IMTGLDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISNALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References