Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2426002..2426642 Replicon chromosome
Accession NZ_CP119862
Organism Citrobacter sp. S171

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P2W74_RS11845 Protein ID WP_276295086.1
Coordinates 2426002..2426178 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P2W74_RS11850 Protein ID WP_276295180.1
Coordinates 2426226..2426642 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W74_RS11825 (2422822) 2422822..2423052 - 231 WP_203361271.1 DUF2554 family protein -
P2W74_RS11830 (2423199) 2423199..2423327 - 129 WP_276295083.1 DUF2474 domain-containing protein -
P2W74_RS11835 (2423327) 2423327..2424337 - 1011 WP_276295084.1 cytochrome d ubiquinol oxidase subunit II -
P2W74_RS11840 (2424337) 2424337..2425740 - 1404 WP_276295085.1 cytochrome ubiquinol oxidase subunit I -
P2W74_RS11845 (2426002) 2426002..2426178 + 177 WP_276295086.1 type II toxin-antitoxin system HicA family toxin Toxin
P2W74_RS11850 (2426226) 2426226..2426642 + 417 WP_276295180.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P2W74_RS11855 (2426759) 2426759..2428168 + 1410 WP_276295087.1 PLP-dependent aminotransferase family protein -
P2W74_RS11860 (2428506) 2428506..2429651 + 1146 WP_276295088.1 ABC transporter substrate-binding protein -
P2W74_RS11865 (2429669) 2429669..2430682 + 1014 WP_276295089.1 ABC transporter ATP-binding protein -
P2W74_RS11870 (2430689) 2430689..2431627 + 939 WP_203361272.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-133)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6754.87 Da        Isoelectric Point: 11.3242

>T274464 WP_276295086.1 NZ_CP119862:2426002-2426178 [Citrobacter sp. S171]
VKQSELRRWLESQGVEVTNGANHLKLRYHGKRSVMPRHPGDEIKEPLRKAILKQLGLR

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15211.38 Da        Isoelectric Point: 4.2978

>AT274464 WP_276295180.1 NZ_CP119862:2426226-2426642 [Citrobacter sp. S171]
MRYPVNLTPAPEGGYVVSFPDIPEALTQGDTRQESLEAAFDALMTALEFYFEDNEPIPQPSVLCDADAYVDVPLSVTSKI
LLLNAFLESSITQQELATRIGKPKQEITRLFDLRHSTKIDTVQAAAKALGKELKLTLV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References