Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 2897138..2897966 Replicon chromosome
Accession NZ_CP119773
Organism Dickeya fangzhongdai strain ZXC1

Toxin (Protein)


Gene name itaT Uniprot ID A0A3A4CQM7
Locus tag PQ617_RS12945 Protein ID WP_024105035.1
Coordinates 2897138..2897674 (-) Length 179 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID -
Locus tag PQ617_RS12950 Protein ID WP_050569822.1
Coordinates 2897655..2897966 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ617_RS12925 (PQ617_12925) 2892542..2893510 + 969 WP_276195893.1 o-succinylbenzoate synthase -
PQ617_RS12930 (PQ617_12930) 2893498..2894877 + 1380 WP_100849132.1 o-succinylbenzoate--CoA ligase -
PQ617_RS12935 (PQ617_12935) 2895084..2895629 + 546 WP_276195895.1 YfaZ family outer membrane protein -
PQ617_RS12940 (PQ617_12940) 2895783..2896976 + 1194 WP_276195897.1 nicotinamide mononucleotide deamidase-related protein YfaY -
PQ617_RS12945 (PQ617_12945) 2897138..2897674 - 537 WP_024105035.1 GNAT family N-acetyltransferase Toxin
PQ617_RS12950 (PQ617_12950) 2897655..2897966 - 312 WP_050569822.1 DUF1778 domain-containing protein Antitoxin
PQ617_RS12955 (PQ617_12955) 2898265..2898545 - 281 Protein_2512 IS4 family transposase -
PQ617_RS12960 (PQ617_12960) 2898648..2899508 - 861 WP_100849133.1 co-chaperone YbbN -
PQ617_RS12965 (PQ617_12965) 2899571..2900347 - 777 WP_038661068.1 SDR family oxidoreductase -
PQ617_RS12970 (PQ617_12970) 2900411..2901052 - 642 WP_050570000.1 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 -
PQ617_RS12975 (PQ617_12975) 2901020..2901706 + 687 WP_033570141.1 putative ABC transporter ATP-binding protein YbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-154)

Antitoxin

Vibrio phage ICP1, Orf50

(11-97)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19327.27 Da        Isoelectric Point: 6.7055

>T274453 WP_024105035.1 NZ_CP119773:c2897674-2897138 [Dickeya fangzhongdai]
MVDTQSESNGVVVYAYQADTTYPGSKSFDCGNTVINSFVRSSLKKSVRDGNCAAKVLVKDETKELLGFCTFAAYSLEKSK
LAGVVSGSLPHELGVVRLIMLGVATKEQNKGYGQELLLEFFKQVKTIHESLPVKGVYLDADPAAIDFYIRLGFVQLNEPP
NAFGAVPMFLAIQHILAA

Download         Length: 537 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11436.04 Da        Isoelectric Point: 10.7931

>AT274453 WP_050569822.1 NZ_CP119773:c2897966-2897655 [Dickeya fangzhongdai]
MSNVSVFPNDTRVTKNARVELKTSPDLKDVLREAATAAGLDLSAFILNAALERAESVLDNQRRRQLSAASWQQLNQLLSE
PAAPTLALQALMRRKKQDGRYSK

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CQM7

Antitoxin

Source ID Structure

References