Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2834717..2835342 Replicon chromosome
Accession NZ_CP119773
Organism Dickeya fangzhongdai strain ZXC1

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag PQ617_RS12705 Protein ID WP_009114000.1
Coordinates 2834717..2834920 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag PQ617_RS12710 Protein ID WP_042859087.1
Coordinates 2834974..2835342 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ617_RS12675 (PQ617_12675) 2830355..2830693 + 339 WP_002208627.1 P-II family nitrogen regulator -
PQ617_RS12680 (PQ617_12680) 2830736..2832028 + 1293 WP_038661206.1 ammonium transporter AmtB -
PQ617_RS12685 (PQ617_12685) 2832121..2832984 - 864 WP_038918195.1 acyl-CoA thioesterase II -
PQ617_RS12690 (PQ617_12690) 2833237..2833797 + 561 WP_038918196.1 YbaY family lipoprotein -
PQ617_RS12695 (PQ617_12695) 2833826..2834155 - 330 WP_038918197.1 MGMT family protein -
PQ617_RS12705 (PQ617_12705) 2834717..2834920 - 204 WP_009114000.1 HHA domain-containing protein Toxin
PQ617_RS12710 (PQ617_12710) 2834974..2835342 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
PQ617_RS12715 (PQ617_12715) 2835850..2835993 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
PQ617_RS12720 (PQ617_12720) 2836009..2836260 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
PQ617_RS12725 (PQ617_12725) 2836431..2839577 - 3147 WP_209126376.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T274452 WP_009114000.1 NZ_CP119773:c2834920-2834717 [Dickeya fangzhongdai]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT274452 WP_042859087.1 NZ_CP119773:c2835342-2834974 [Dickeya fangzhongdai]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References