Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 135630..136216 Replicon chromosome
Accession NZ_CP119753
Organism Microbacter sp. GSS18

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P0L94_RS00630 Protein ID WP_276178145.1
Coordinates 135630..135998 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag P0L94_RS00635 Protein ID WP_276178147.1
Coordinates 135995..136216 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0L94_RS00605 (P0L94_00605) 131040..131687 + 648 WP_276178135.1 SDR family oxidoreductase -
P0L94_RS00610 (P0L94_00610) 132099..132938 - 840 WP_276178137.1 NADPH-dependent oxidoreductase -
P0L94_RS00615 (P0L94_00615) 132996..133976 - 981 WP_276178139.1 acyl-CoA desaturase -
P0L94_RS00620 (P0L94_00620) 134341..134658 - 318 WP_276178141.1 hypothetical protein -
P0L94_RS00625 (P0L94_00625) 134892..135626 + 735 WP_276178143.1 aminoglycoside 3'-phosphotransferase -
P0L94_RS00630 (P0L94_00630) 135630..135998 - 369 WP_276178145.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P0L94_RS00635 (P0L94_00635) 135995..136216 - 222 WP_276178147.1 antitoxin Antitoxin
P0L94_RS00640 (P0L94_00640) 136367..136819 - 453 WP_276178149.1 hypothetical protein -
P0L94_RS00645 (P0L94_00645) 136937..138208 - 1272 WP_276178151.1 NAD(P)/FAD-dependent oxidoreductase -
P0L94_RS00650 (P0L94_00650) 138322..139767 + 1446 Protein_129 cryptochrome/photolyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 12740.62 Da        Isoelectric Point: 11.6142

>T274421 WP_276178145.1 NZ_CP119753:c135998-135630 [Microbacter sp. GSS18]
VSDALPLLRRGHIVLVNLDPAVGSEAAKTRPAIVVSNNTANASALRSDRGVITVVPLTSNVARVHGFQVLVDPESSGLTR
TSKAQAERVRTVSIARVSAVTGWLGAEQMGAVDAALRLHLSL

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7768.36 Da        Isoelectric Point: 3.7542

>AT274421 WP_276178147.1 NZ_CP119753:c136216-135995 [Microbacter sp. GSS18]
MSYAKVSLSLSDADVAFLDSETLSGAYPSRSAAVQDAARMLRESRLADAYAQAFEEWDDDAWDATSGDGISAA

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References