Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 16056..16591 Replicon plasmid pE15-3
Accession NZ_CP119749
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8WEY8
Locus tag P1J19_RS26095 Protein ID WP_032353555.1
Coordinates 16056..16343 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WHE0
Locus tag P1J19_RS26100 Protein ID WP_045145550.1
Coordinates 16340..16591 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS26075 (P1J19_26075) 11237..12424 + 1188 WP_045145541.1 IS91 family transposase -
P1J19_RS26080 (P1J19_26080) 13278..13871 + 594 WP_032353553.1 ProQ/FINO family protein -
P1J19_RS26085 (P1J19_26085) 14151..14738 - 588 WP_064550130.1 colanic acid biosynthesis acetyltransferase -
P1J19_RS26090 (P1J19_26090) 15759..16046 - 288 WP_045145547.1 hypothetical protein -
P1J19_RS26095 (P1J19_26095) 16056..16343 - 288 WP_032353555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1J19_RS26100 (P1J19_26100) 16340..16591 - 252 WP_045145550.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1J19_RS26105 (P1J19_26105) 16678..16845 - 168 WP_065898644.1 hypothetical protein -
P1J19_RS26110 (P1J19_26110) 17540..18412 - 873 WP_045145554.1 incFII family plasmid replication initiator RepA -
P1J19_RS26115 (P1J19_26115) 19248..19754 + 507 WP_024187405.1 transcription termination/antitermination NusG family protein -
P1J19_RS26120 (P1J19_26120) 19895..20560 + 666 WP_065203167.1 traC -
P1J19_RS26125 (P1J19_26125) 20827..21447 + 621 WP_032353888.1 DUF1449 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..129738 129738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.16 Da        Isoelectric Point: 10.6261

>T274417 WP_032353555.1 NZ_CP119749:c16343-16056 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9219.48 Da        Isoelectric Point: 4.1789

>AT274417 WP_045145550.1 NZ_CP119749:c16591-16340 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHYVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WHE0

References