Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4321887..4322482 Replicon chromosome
Accession NZ_CP119746
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag P1J19_RS20950 Protein ID WP_000239579.1
Coordinates 4321887..4322237 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag P1J19_RS20955 Protein ID WP_001223208.1
Coordinates 4322231..4322482 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS20930 (4317163) 4317163..4318185 - 1023 WP_001296689.1 ABC transporter permease -
P1J19_RS20935 (4318199) 4318199..4319701 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
P1J19_RS20940 (4320011) 4320011..4320967 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P1J19_RS20945 (4321277) 4321277..4321807 + 531 WP_000055072.1 inorganic diphosphatase -
P1J19_RS20950 (4321887) 4321887..4322237 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
P1J19_RS20955 (4322231) 4322231..4322482 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P1J19_RS20960 (4322694) 4322694..4323035 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P1J19_RS20965 (4323038) 4323038..4326799 - 3762 WP_276170941.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T274406 WP_000239579.1 NZ_CP119746:c4322237-4321887 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT274406 WP_001223208.1 NZ_CP119746:c4322482-4322231 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References