Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3613757..3614375 Replicon chromosome
Accession NZ_CP119746
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J19_RS17615 Protein ID WP_001291435.1
Coordinates 3614157..3614375 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J19_RS17610 Protein ID WP_000344800.1
Coordinates 3613757..3614131 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS17600 (3608846) 3608846..3610039 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J19_RS17605 (3610062) 3610062..3613211 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J19_RS17610 (3613757) 3613757..3614131 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J19_RS17615 (3614157) 3614157..3614375 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J19_RS17620 (3614546) 3614546..3615097 + 552 WP_000102564.1 maltose O-acetyltransferase -
P1J19_RS17625 (3615213) 3615213..3615683 + 471 WP_000136192.1 YlaC family protein -
P1J19_RS17630 (3615847) 3615847..3617397 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J19_RS17635 (3617439) 3617439..3617792 - 354 WP_000878141.1 DUF1428 family protein -
P1J19_RS17645 (3618171) 3618171..3618482 + 312 WP_000409911.1 MGMT family protein -
P1J19_RS17650 (3618513) 3618513..3619085 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274403 WP_001291435.1 NZ_CP119746:3614157-3614375 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274403 WP_000344800.1 NZ_CP119746:3613757-3614131 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References