Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2612525..2613163 Replicon chromosome
Accession NZ_CP119746
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P1J19_RS12745 Protein ID WP_000813794.1
Coordinates 2612987..2613163 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P1J19_RS12740 Protein ID WP_001270286.1
Coordinates 2612525..2612941 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS12720 (2607677) 2607677..2608618 - 942 WP_001251315.1 ABC transporter permease -
P1J19_RS12725 (2608619) 2608619..2609632 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P1J19_RS12730 (2609650) 2609650..2610795 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P1J19_RS12735 (2611040) 2611040..2612446 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
P1J19_RS12740 (2612525) 2612525..2612941 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P1J19_RS12745 (2612987) 2612987..2613163 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P1J19_RS12750 (2613385) 2613385..2613615 + 231 WP_000494244.1 YncJ family protein -
P1J19_RS12755 (2613707) 2613707..2615668 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P1J19_RS12760 (2615741) 2615741..2616277 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P1J19_RS12765 (2616369) 2616369..2617544 + 1176 WP_001236215.1 BenE family transporter YdcO -
P1J19_RS12770 (2617584) 2617584..2617898 - 315 Protein_2500 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2612525..2629078 16553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274402 WP_000813794.1 NZ_CP119746:c2613163-2612987 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT274402 WP_001270286.1 NZ_CP119746:c2612941-2612525 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References