Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4647909..4648406 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P1J23_RS23355 Protein ID WP_001173343.1
Coordinates 4647909..4648082 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag P1J23_RS23360 Protein ID WP_001425728.1
Coordinates 4648110..4648406 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS23345 (4644579) 4644579..4646036 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
P1J23_RS23350 (4646273) 4646273..4647790 + 1518 WP_001295074.1 lysine--tRNA ligase -
P1J23_RS23355 (4647909) 4647909..4648082 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P1J23_RS23360 (4648110) 4648110..4648406 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P1J23_RS23365 (4648633) 4648633..4648905 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P1J23_RS23370 (4648917) 4648917..4649147 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
P1J23_RS23375 (4649328) 4649328..4650959 + 1632 WP_001216487.1 sensor histidine kinase -
P1J23_RS23380 (4650956) 4650956..4651675 + 720 Protein_4582 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T274381 WP_001173343.1 NZ_CP119740:c4648082-4647909 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT274381 WP_001425728.1 NZ_CP119740:c4648406-4648110 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References